Drive through beautiful South Park via Highway 285, heading south and passing through Fairplay, near Buena Vista, through Saguache, over Wolf Creek Pass, and into Pagosa Springs. Continue on Highway 160 west from Pagosa Springs through Durango and Hesperus until you reach the town of Mancos. , then follow the directions below from Mancos. At Mancos, turn on Highway 184 toward Dolores (you can lay over a night in the comfortable yurts or campsites at Mancos State Park). Follow the directions from Dolores below. Total distance from Denver is about 400 miles. Depending on weather conditions, road construction, and other variables, routes through Grand Junction or south through Pueblo/ Walsenburg/Alamosa/Monte Vista are also options.
Take Highway 160 east from Cortez towards Mancos and Durango then turn north on Highway 145 towards Dolores, then follow the directions from Dolores below.
From Dolores, you'll take Forest Roads 526 and 514 north and west to the park.